Pharmacological Profile of a New Cyclohepten Sympathomimetic
نویسندگان
چکیده
* Communication No . 1821 from Central Drug Research Institute, Lucknow, India Abstract-Pharmacological profile of a new sympathomimetic agent, compound 70-352, is reported herein. This compound was found to directly stimulate a-ad renergic receptors in the cat, guinea pig, rabbit and rat. Activity was similar to that of noradrenaline (NA) but it was only 0.032% as potent as NA on isolated rat uterus. Duration of action of the compound was, however, much longer. Compound 70 352 had no effect on the central nervous system and the acute LD50 in mice was 1000.0 mg/kg i.p.
منابع مشابه
Pharmacological Profile of Oxazine and its Derivatives: A Mini Review
Oxazine derivatives are significant class of heterocycle compounds, which has involved much synthetic attention due to their extensive variety of pharmacological activities. Oxazine is a heterocyclic compound can be formally derived from benzene, and its reduction products, by suitable substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few years oxazine derivatives ...
متن کاملPositioning new pharmacotherapies for COPD
COPD imposes considerable worldwide burden in terms of morbidity and mortality. In recognition of this, there is now extensive focus on early diagnosis, secondary prevention, and optimizing medical management of the disease. While established guidelines recognize different grades of disease severity and offer a structured basis for disease management based on symptoms and risk, it is becoming i...
متن کاملAkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro
Background: Intraoperative hypotension is a common problem and direct or indirect sympathomimetic drugs are frequently needed to stabilize blood pressure. AkrinorTM consists of the direct and the indirect sympathomimetic noradrenaline and norephedrine. Both substances are covalently bound to the phosphodiesterase (PDE) inhibitor theophylline, yielding theodrenaline and cafedrine, respectively. ...
متن کاملThe sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens.
1. The peripheral, pharmacological effects of the anorexigenic agent, fenfluramine hydrochloride, have been investigated on rat isolated vas deferens. 2. Characteristic spiked contractions were observed within 2 to 3 min after exposure to fenfluramine; these contractions reached a rate of around 13 per min and were of variable height. 3. Pre-treatment of vasa with the indirectly acting sympatho...
متن کاملMarine pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action.
This review, a sequel to the 1998 review, classifies 63 peer-reviewed articles on the basis of the reported preclinical pharmacological properties of marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. In all, 21 marine chemicals demonstrated anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis or antiviral ...
متن کامل